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simbiology module (2017a)  (MathWorks Inc)


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    MathWorks Inc simbiology module (2017a)
    Simulation of antibody in footpad injection depot. (a) One-compartment model diagramed using the Matlab <t>Simbiology</t> module <t>(2017a)</t> with the simulations governed by the equations described in Methods and Materials. Since it was assumed that no other anatomical structure or physiological mechanism was involved in the clearance, the depot is the single compartment in which the gel was injected, with “Ab_Z15EAK” representing IgG800 complexed with Z15_EAK/EAK coacervate, “Ab” representing dissociated IgG800, and “Z15EAK” representing Z15_EAK and EAK (which were assumed to remain always in the depot); reaction_1 represents reversible binding (kon and koff) between antibody and Z15, and reaction_2 represents elimination of antibody from the depot (kel); (b) Fitting of in vivo decay data in Fig. 6 to first-order elimination model to obtain kel; (d) Simulated profiles of the complex, Z15_EAK/EAK composite, and free antibody using Kd determined in ITC and the microplate assay. AUC was calculated using a trapezoidal numerical integration function in Matlab.
    Simbiology Module (2017a), supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/simbiology module (2017a)/product/MathWorks Inc
    Average 90 stars, based on 1 article reviews
    simbiology module (2017a) - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "Toward Reducing Biomaterials Antigenic Potential: A Miniaturized Fc-Binding Domain for Local Deposition of Antibodies"

    Article Title: Toward Reducing Biomaterials Antigenic Potential: A Miniaturized Fc-Binding Domain for Local Deposition of Antibodies

    Journal: Biomaterials science

    doi: 10.1039/c8bm01220b

    Simulation of antibody in footpad injection depot. (a) One-compartment model diagramed using the Matlab Simbiology module (2017a) with the simulations governed by the equations described in Methods and Materials. Since it was assumed that no other anatomical structure or physiological mechanism was involved in the clearance, the depot is the single compartment in which the gel was injected, with “Ab_Z15EAK” representing IgG800 complexed with Z15_EAK/EAK coacervate, “Ab” representing dissociated IgG800, and “Z15EAK” representing Z15_EAK and EAK (which were assumed to remain always in the depot); reaction_1 represents reversible binding (kon and koff) between antibody and Z15, and reaction_2 represents elimination of antibody from the depot (kel); (b) Fitting of in vivo decay data in Fig. 6 to first-order elimination model to obtain kel; (d) Simulated profiles of the complex, Z15_EAK/EAK composite, and free antibody using Kd determined in ITC and the microplate assay. AUC was calculated using a trapezoidal numerical integration function in Matlab.
    Figure Legend Snippet: Simulation of antibody in footpad injection depot. (a) One-compartment model diagramed using the Matlab Simbiology module (2017a) with the simulations governed by the equations described in Methods and Materials. Since it was assumed that no other anatomical structure or physiological mechanism was involved in the clearance, the depot is the single compartment in which the gel was injected, with “Ab_Z15EAK” representing IgG800 complexed with Z15_EAK/EAK coacervate, “Ab” representing dissociated IgG800, and “Z15EAK” representing Z15_EAK and EAK (which were assumed to remain always in the depot); reaction_1 represents reversible binding (kon and koff) between antibody and Z15, and reaction_2 represents elimination of antibody from the depot (kel); (b) Fitting of in vivo decay data in Fig. 6 to first-order elimination model to obtain kel; (d) Simulated profiles of the complex, Z15_EAK/EAK composite, and free antibody using Kd determined in ITC and the microplate assay. AUC was calculated using a trapezoidal numerical integration function in Matlab.

    Techniques Used: Injection, Binding Assay, In Vivo



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    simbiology module (2017a)  (MathWorks Inc)
    90
    MathWorks Inc simbiology module (2017a)
    Simulation of antibody in footpad injection depot. (a) One-compartment model diagramed using the Matlab <t>Simbiology</t> module <t>(2017a)</t> with the simulations governed by the equations described in Methods and Materials. Since it was assumed that no other anatomical structure or physiological mechanism was involved in the clearance, the depot is the single compartment in which the gel was injected, with “Ab_Z15EAK” representing IgG800 complexed with Z15_EAK/EAK coacervate, “Ab” representing dissociated IgG800, and “Z15EAK” representing Z15_EAK and EAK (which were assumed to remain always in the depot); reaction_1 represents reversible binding (kon and koff) between antibody and Z15, and reaction_2 represents elimination of antibody from the depot (kel); (b) Fitting of in vivo decay data in Fig. 6 to first-order elimination model to obtain kel; (d) Simulated profiles of the complex, Z15_EAK/EAK composite, and free antibody using Kd determined in ITC and the microplate assay. AUC was calculated using a trapezoidal numerical integration function in Matlab.
    Simbiology Module (2017a), supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/simbiology module (2017a)/product/MathWorks Inc
    Average 90 stars, based on 1 article reviews
    simbiology module (2017a) - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Simulation of antibody in footpad injection depot. (a) One-compartment model diagramed using the Matlab Simbiology module (2017a) with the simulations governed by the equations described in Methods and Materials. Since it was assumed that no other anatomical structure or physiological mechanism was involved in the clearance, the depot is the single compartment in which the gel was injected, with “Ab_Z15EAK” representing IgG800 complexed with Z15_EAK/EAK coacervate, “Ab” representing dissociated IgG800, and “Z15EAK” representing Z15_EAK and EAK (which were assumed to remain always in the depot); reaction_1 represents reversible binding (kon and koff) between antibody and Z15, and reaction_2 represents elimination of antibody from the depot (kel); (b) Fitting of in vivo decay data in Fig. 6 to first-order elimination model to obtain kel; (d) Simulated profiles of the complex, Z15_EAK/EAK composite, and free antibody using Kd determined in ITC and the microplate assay. AUC was calculated using a trapezoidal numerical integration function in Matlab.

    Journal: Biomaterials science

    Article Title: Toward Reducing Biomaterials Antigenic Potential: A Miniaturized Fc-Binding Domain for Local Deposition of Antibodies

    doi: 10.1039/c8bm01220b

    Figure Lengend Snippet: Simulation of antibody in footpad injection depot. (a) One-compartment model diagramed using the Matlab Simbiology module (2017a) with the simulations governed by the equations described in Methods and Materials. Since it was assumed that no other anatomical structure or physiological mechanism was involved in the clearance, the depot is the single compartment in which the gel was injected, with “Ab_Z15EAK” representing IgG800 complexed with Z15_EAK/EAK coacervate, “Ab” representing dissociated IgG800, and “Z15EAK” representing Z15_EAK and EAK (which were assumed to remain always in the depot); reaction_1 represents reversible binding (kon and koff) between antibody and Z15, and reaction_2 represents elimination of antibody from the depot (kel); (b) Fitting of in vivo decay data in Fig. 6 to first-order elimination model to obtain kel; (d) Simulated profiles of the complex, Z15_EAK/EAK composite, and free antibody using Kd determined in ITC and the microplate assay. AUC was calculated using a trapezoidal numerical integration function in Matlab.

    Article Snippet: Calculations of the relative exposures (AUC) indicate 0.27 fraction of the antibody injected existed as unbound during the 28-day period. fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 7: caption a7 Simulation of antibody in footpad injection depot. (a) One-compartment model diagramed using the Matlab Simbiology module (2017a) with the simulations governed by the equations described in Methods and Materials.

    Techniques: Injection, Binding Assay, In Vivo